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KMID : 0931320090090020075
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대한상부위장관.헬리코박터학회지
2009 Volume.9 No. 2 p.75 ~ p.81
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Effect of Short-term Fasting on the Methotrexate Induced Weight Changes and Bacterial Translocation in a Rat Model
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Kim Jeong-Wook
Jeon Woo-Kyu
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Abstract
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Background/Aims: Methotrexate (MTX) induce body and organ weight loss and bacterial translocation (BT). Fasting cause weight loss and enteric bacterial overgrowth with increasing BT. We examined the effects of short term fasting on the MTX induced weight changes and BT.
Methods: Rats were divided into 4 group (control group; MTX group; MTX with 24 hour fasting group; MTX with 72 hour fasting group). Rats with MTX received MTX 25 mg/kg orally. Intestinal permeability (IP) and fecal pellet output, bacterial numbers in distal ileal and cecal contents and the BT to mesenteric lymph nodes (MLNs), liver, spleen, kidney and heart, and body and organ weight changes were measured.
Results: MTX administration caused body and liver weight loss regardless amounts of food intakes. MTX induced increasing IP, cecal gram negative undergrowth and BT to MLNs, liver and spleen, but did not change fecal pellet output. Additional fasting increased MTX induced body and liver weight loss and caused cecal gram negative overgrowth, but not influenced MTX induced increasing IP and BT.
Conclusions: Short term fasting increased MTX induced body and liver weight loss, but not influenced MTX induced gut barrier dysfunction and BT despite of cecal gram negative overgrowth. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2009;9:75-81)
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KEYWORD
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Methotrexate, Fasting, Weight loss, Bacterial translocation
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